Omeprazole is an inexpensive drug used to treat certain conditions where there is too much acid in the stomach like ulcers and gastroesophageal reflux disease ().It is more popular than comparable drugs. It is available in both generic and brand versions, and without a prescription. Generic omeprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may. Sucralfate (Carafate) and misoprostol (Cytotec) Sucralfate and misoprostol are agents that strengthen the gut lining against attacks by acidic digestive juices. Sucralfate coats the ulcer surface and promotes healing. Sucralfate has very few side effects.